berger

Not to mention the paper itself is a source of at least some of the carcinogens involved. Damn dirty business for sure.
That's why I like vaping doing this to BT:

Attached Thumbnails

MattZuke

I was the same way myself at first starting at 18mg, until I started playing with the kr808-1.

Mainstream cigs contain diammonium phosphate, ammonium hydroxide, and other chemicals mainly in the reconstituted tobacco, which deal with nicotine manipulation. You can find some info in this vid. The end result is freebase nicotine, more potent, more easily absorbed.

AFAIK vaping is absorbed much in the same way, but without the extra chemicals dealing with nicotine manipulation. There is no independent research that I'm aware of on this delivery method, nor the long term affects of ANY Nicotine Reduction Product.

berger

Nicotine is being considered as a therapeutic agent to treat such conditions as attention deficit disorder, Alzheimer's Disease, Parkinson's Disease, Tourette syndrome, sleep apnea, obesity, ulcerative colitis, obesity, and inflammatory skin disorders.
Nicotine has the following benefits:
Relieves depression
Reduces anxiety
Improves ability to concentrate and long term memory
Protects against developing high blood pressure
Protects against weight gain
Protects against developing Parkinson's Disease

MattZuke

Yes, it's a drug, it has therapeutic properties. I'm skeptical on weight gain, high blood pressure, and the others. There is NO research on the long term affects of nicotine use outside the standard flaming delivery method. This is what backed the FDA and others into a corner, since they approved various NRPs, but reject vaporizing when they skirted the issue on NRPs in the first place since they are not intended for long term use.

Dhileas

It also benefits those with ADHD. Nicotine is also suggested to reduce the risk of breast cancer in women that have a particularly high risk of breast cancer via genetics and early research is showing potential neurological benefits on sufferers of Huntington's Disease and Alzheimer's Disease.

HiRezL

If only we could get away with it . . . I always tell my wife, the person who invents a safe, legal over-the-counter kiddie tranquilizer will be a multi-millionaire.

quasimod

Oh, he was!

quasimod

Weird iPhone double-post, sorry.

Steampunk

Pretty much what I said after about three weeks of vaping. There's something else in a ciggy that cures the craving other than nicotine.

All that said, I actually did pretty well today...only two ciggies. I had been breaking the Golden Rule and carrying a pack in the car with me, and had gotten back to 6-8 cigs a day. However, when I get frustrated I tend to go to the higher range (6-8), but not having them today was a bit harrowing. But, the CE2s did the trick...

Steampunk

or vodka.

Steampunk

I got a spam yesterday: Get Thorazine CHEAP!

Yup! I want to walk around like a zombie!!!

As one of my psych profs used to say, "The 1000CC straightjacket..."

Dhileas

Nothing is better than a pair of caudal blocks between L-4 & L-6. That's... simply... divine!!!

MattZuke

Freebase nicotine is the most rational explanation. Something like Marbs are often cited as having 10% when extracted, others at high as 35% which INCLUDES American Spirit, so called additive free. This explains why I was shocked when I fell off the wagon American Spirits addressed the addition to cigs. Camels oddly enough only produce ~3% when burned, much to my shock.

I'd have to check, but I doubt 150f-250f is hot enough to freebase the nicotine even if the right phosphates were added to e-fluid.

PH is a factor as well. Pipe/cigar tobacco tends to be more alkaline, harsher on the lungs, slower nicotine absorption, but much easier to absorb through the skin, mainly the mouth. See "The scientific basis of tobacco product regulation: report of a WHO Study Group"

Steampunk

spammer?

HiRezL

Multiple thread spamming, put him in the hall!

berger

Actually, studies have shown there is more then just nicotine that is contributing to the additive properties of tobacco. They are finding marked decreases in MAO levels (A&B) not attributable to the nicotine resulting in higher levels of Dopamine. Also animal studies have indicated acetaldehyde, another chemical found in tobacco smoke, dramatically increases the reinforcing properties of nicotine.

MattZuke

Hey, always happy to add this to my database. Happen to have a decent citation for this? In any case, you've got the free-base nicotine, as with free-base cocaine, drastically increases the potency.

berger

Matt, Took a while to find it again but here's a link:
http://www.drugabuse.gov/PDF/TobaccoRRS_v16.pdf

MattZuke

The actual citation
Belluzzi, J.D.; Wang, R.; and Leslie,
F.M. Acetaldehyde enhances acquisition of nicotine self-administration in
adolescent rats. Neuropsychopharmacol 30:705–712, 2005.

The actual study showed that adolescent were more prone to the reenforcement to acetaldehyde than adults, and adult rats given the choice would opt for cocaine over nicotine with acetaldehyde. But still, valid citation.

Here's the actual study hosted on Nature, with a host of other useful information. Nature is a peer reviewed publication.
Neuropsychopharmacology - Acetaldehyde Enhances Acquisition of Nicotine Self-Administration in Adolescent Rats

berger

Matt.. just curious..you said database earlier...what do you do?

MattZuke

Just your run of the mill consultant, but I read at 240 characters per second on a slow day. I just chatted up my local dealer and she's hip to the jive of confronting the local health department as a preemptive strike, as opposed to Seattle which put forth a thumbs down.

The idea is to convince them we're actually on the same side, and using existing research to demonstrate what the prevailing medical opinion has been on NRPs to date which is who cares about the long term affects 'cause anything beats smoking.

berger

Thats great! I wish you success as that may help all of us.